Its Full Of Acids And Fibers
Thiamine in the human body provides carbohydrate metabolism in the brain, tissues, liver. Vitamin coenzyme fights the so-called fatigue toxins lactic, pyruvic acid. Their excess leads to lack of energy, overwork, lack of vitality. The negative effect of carbohydrate metabolism products neutralizes carboxylase, turning them into glucose which nourishes the brain cells. Given the above, thiamin can be called a vitamin of pep, optimism because it improves mood, removes depression, soothes nerves, and returns appetite.
Hierarchical Order Of Thiamine
While it could be assumed that a deficiency in a given micronutrient affects its dependent enzymes equally, experimental evidence indicates otherwise. For instance, copper deficiency severely reduces cytochrome c oxidase activity affecting copper/zinc-superoxide dismutase to a lesser extent . Moreover, this hierarchical order is also tissue-specific as different brain areas . Similarly, in the case of thiamine deficiency, the most affected brain regions seem to be cerebellum, mammillary bodies, thalamus, hypothalamus, and brainstem in adults . In children, MRI studies showed primary involvement of mammillary bodies as well as basal ganglia , in addition to frontal lobes .
In cases of severe thiamine deficiency, however, a broad enzymatic deficiency encompassing all three mitochondrial TPP-dependent enzymes would be expected to result in symptoms similar to those of the genetic disorder dihydrolipoamide dehydrogenase deficiency . This pathogenic mutation affects the E3 subunit, common to all three TPP-dependent dehydrogenases. Patients clinically present with lactic acidosis and neurodegeneration from inefficient oxidative metabolism, as well as increased BCAA concentrations and -keto acids in the urine, with many of the same symptoms as MSUD, but with a more severe phenotype .
Who Is At Risk Of B1 Deficiency
People with poor diet, cancer, morning sickness during pregnancy, bariatric surgery, and hemodialysis are at risk of thiamin deficiency.
People who regularly drink alcohol to excess may have a deficiency, as they may not absorb thiamin from their food.
Wernicke-Korsakoff syndrome is a disorder that affects people with chronic alcoholism. It is linked to a lack of thiamin, and it can be fatal if not treated.
People with Wernicke-Korsakoff syndrome and those who are withdrawing from alcohol may receive thiamin injections to help them recover.
Other diseases, such as HIV, can reduce the absorption of nutrients, and this can lead to a deficiency of vitamin B1.
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Vitamin B12 Benefits: Take The Next Step
Vitamin B12 is essential for a healthy brain and nervous system.
Its also protective for a wide range of mental and physical health conditions.
Although vitamin B12 is readily found in animal food sources, there are many factors that can interfere with its absorption, including age, medications, and gastrointestinal health.
The impact of a vitamin B12 deficiency can be very serious.
If you have any doubt that youre deficient, have your vitamin B12 level tested.
If your level is below normal, take steps to increase your intake of B12.
Eat more foods rich in vitamin B12, take a high-quality vitamin B12 supplement, and discuss whether you could benefit from oral B12 mega-doses or B12 injections with your doctor.
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Vitamin B12 Food Sources
Most people get plenty of vitamin B12 in their diets.
Its found in animal foods of all kinds meat, poultry, pork, fish, seafood, dairy, and eggs.
” Although vitamin B12 is readily found in animal food sources, there are many factors that can interfere with its absorption, including age, medications, and gastrointestinal health.
The two best sources of B12 are clams and beef liver they contain 60 times more vitamin B12 than beef and over 100 times more than eggs.
But for those who dont eat animal products, getting adequate B12 is a serious concern.
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Brain Balance And Nutrition
As part of The Brain Balance Program, weve designed a proprietary nutrition system that busy parents can easily follow to manage a childs nutrition and optimize a balanced brain. The Balance 360 System is specifically designed to help children become healthy eaters. The stepped approach that is Balance 360 helps you move from unhealthy eating habits to extremely healthy eating habits. With Balance 360, health improves as does performance and behavior!
To learn why our whole-child approach is the most effective way to help your child overcome their learning, behavior, and social challenges, contact us online or find a center near you.
Perspective On Alzheimers Disease
Alzheimers disease is defined by a progressive cognitive deterioration and neuropathological changes in the brain that consist of deposition of extracellular beta amyloid plaques and intracellular neurofibrillary tangles made of hyperphosphorylated tau proteins.4, 5 This definition is equivocal for many reasons for example, many controls have plaques at autopsy and an emerging literature also indicates that as many as 35% of the patients diagnosed with AD by comprehensive cognitive testing do not have plaques.6, 7 This begs the question of whether the plaques and NFTs are causative of AD or just one of many downstream consequences.
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Benefits Of Vitamin B12
Vitamin B12 plays an important role in many physiological functions and protects against a variety of health problems.
It is one of the many nutrients required for building strong bones and warding off osteoporosis.
B12 protects against heart disease by removing the toxic amino acid homocysteine from the bloodstream.
It may reduce the severity and frequency of allergies and asthma attacks.
Vitamin B12 is essential for healthy hair, nails, and skin and is sometimes prescribed to topically treat eczema and psoriasis.
It is sometimes used to relieve the pain and nerve damage of shingles.
When taken with other B vitamins, it reduces the risk of macular degeneration, an eye disease that eventually leads to blindness.
How Vitamin B12 Benefits The Brain
Last updated August 31, 2022.Edited and medically reviewed by Patrick Alban, DC. Written by Deane Alban.
Vitamin B12 has critical benefits for the brain and nervous system, yet many are deficient in B12 because they cannot absorb it. Learn how to remedy this.
Vitamin B12 is one of eight essential B vitamins.
It is essential for overall health, but plays an especially important role in keeping the brain and nervous system working properly.
Vitamin B12 deficiency, however, is surprisingly common, affecting nearly half of all adults.
Find out if you may be at risk for deficiency and how to effectively raise your B12 level to improve your mental health and brain function.
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Thiamine Is Used For Complex Therapy
Vitamin B1 thiamine is widely used as therapy drug as it has various benefits to treat Arrhythmias , With alcohol intoxication, Heart, kidney, respiratory, liver failure, Hyperglycemic coma in diabetes mellitus, Muscle paralysis, Multiple sclerosis, Leia syndrome, Metabolic or lactic acidosis in diabetes mellitus, Coronary circulation insufficiency in ischemic heart disease, For weight loss , Diphtheria, scarlet fever, typhoid, Multiple sclerosis, Myocardial infarction, Emplaksii and preeclampsia in pregnant women.
Vitamin B1 And Hashimotos Thyroiditis
Researchers in Italy hypothesized that the chronic fatigue accompanying inflammatory and autoimmune diseases is a clinical manifestation of mild thiamine deficiency.
Hashimotos thyroiditis is both an autoimmune disease and cause of hypothyroidism. In this study, 3 Hashimotos patients complaining of chronic fatigue were recruited.
All 3 patients received 600 mg of thiamine per day, or 100 mg of thiamine intravenously once every 4 days. Thiamine treatment led to partial or complete remission of fatigue within a few hours or days.
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Vitamin B1 And Health
Because thiamin is involved in several basic cell functions and the breakdown of nutrients for energy, a deficiency can lead to various problems in the brain and heart that require a constant supply of energy.
A deficiency of thiamin can lead to abnormal motor functions in the heart. Congestive heart failure is a condition that prevents the heart from properly pumping blood to the rest of the body. The rate of thiamine deficiency in people with congestive heart failure ranges from 21%-98%. It occurs particularly in the elderly, those with a poor nutritional intake, or with the use of high doses of diuretics. Some clinical trials have found that thiamin supplementation compared with a placebo can significantly improve heart function in people with heart failure.
Research has shown that thiamin deficiency can lead to neurological problems such as cognitive decline. One form of thiamin deficiency called Wernicke-Korsakoff syndrome exhibits mental status changes similar to Alzheimers disease. Animal studies suggest that a lack of thiamin may cause oxidative stress or the death of nerve cells, memory loss, formation of plaque, and reduced glucose metabolism, which are all risk factors for Alzheimers disease. Research in humans has been limited, so it is not yet clear if thiamin supplementation can help this condition.
Vitamin B1 Improves Symptoms Of Fibromyalgia
If youve ever had to deal with fibromyalgia, you are familiar with the hell of living with chronic pain, fatigue, insomnia and more.
Some studies suggest that many of the symptoms of fibromyalgia could be related to mild thiamine deficiency due to a dysfunction of the active transport of thiamine from blood to the mitochondria.
One very small study conducted in Italy recruited 3 female patients with fibromyalgia. Levels of thiamine and thiamine pyrophosphate in the blood were measured. The patients then received from 600 mg to 1800 mg of thiamine per day. And the results were astounding:
- Patient 1: 3% reduction in fatigue 80% reduction in pain
- Patient 2: 37% reduction in fatigue 50% reduction in pain
- Patient 3: 7% reduction in fatigue 60% reduction in pain
One patient reported improvement at 600 mg of thiamine. Doses for the other 2 patients were increased by 300 mg every 3 days. And experienced improvement in their symptoms at a dose of 1500 mg. None of the patients experienced side effects.
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Kid Friendly Foods That Contain Vitamin B1 Thiamine
Since B vitamins like Thiamine are water-soluble and not stored in the body, its important to get adequate amounts daily through food. Most of the top sources of Vitamin B1 are wheat-based or from milk which are not recommended due to potential food sensitivities. Here are some alternative sources of thiamin that are kid-friendly, healthy and delicious.
- Sunflower Seeds
- Rice and Rice Bran
Cerebral Effects Of B12 Deficiency
B12 deficiency is another B vitamin deficiency that can trigger mania, psychosis and paranoid delusions, and this has also been known since the mid-1950s. As noted in a 1956 paper titled Cerebral Manifestations of Vitamin B12 Deficiency published in the British Medical Journal:8,
- In a series of 25 cases of vitamin B12 deficiency syndrome with involvement of the nervous system I have encountered 14 cases with well-marked cerebral symptoms
- The mental symptoms are extremely variable and include mild disorders of mood, mental slowness, memory defect which may be gross, confusion, severe agitation and depression, delusions and paranoid behavior, visual and auditory hallucinations violent maniacal behavior and epilepsy.
- None of these symptoms is pathognomonic , and in their absence of anemia or of spinal signs the diagnosis of vitamin B12 deficiency may never be considered until the psychosis is far too advanced to respond to treatment.
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May Prevent Heart Diseases
This vitamin helps in the production of the neurotransmitter acetylcholine, which is used to relay messages between the nerves and muscles and to ensure proper cardiac function. Vitamin B1 deficiency can, therefore, result in irregular cardiac functions. When given vitamin B1 intravenously for seven days, people suffering from congestive heart failure showed considerable improvements in their echocardiograms, and this proves that it can prevent heart disease.
Impact On Hair And Skin
Thiamine has a direct effect on the condition of the hair but a lack of a compound in the body does not immediately affect the structure of the locks. In 95% of cases, the first symptoms of a nutrient deficiency are rapid fatigue, irritability, nervousness, tachycardia, muscle weakness, a decrease in blood pressure. Then, due to metabolic disorders the hair loses its natural luster, elasticity and strength. The daily intake of 1.5 milligrams of thiamine will help fill the lack of nutrient. If during six months the physiological need for vitamin is fully replenished, the process of gradual bonding of hair scales will start and as a result the problems will be eliminated. The benefits are
- Strengthening curls
- Slowing the early appearance of gray hair
- Increase the brightness of color
- Prevention of hair loss from the bulb
- Elimination of dry or oily seborrhea
- Saturation of hair with nutrients
In order to accelerate the restoration of the hair structure this vitamin can be additionally used externally, in the form of masks.
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Mental Health Benefits Of B12
But where vitamin B12 is really crucial is in keeping the brain and nervous system healthy and functioning well.
B12 is needed to form memories and to focus and concentrate.
Low B12 levels are associated with depression.
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Some researchers believe that the link between B12 deficiency and dementia and psychiatric disorders is so strong that patients with these conditions should have their B12 level closely monitored for life.
Brain Glucose Metabolism Like That Of Other Tissues Requires Thiamine At Critical Regulatory Steps And Has Unique Features
Thiamine-dependent enzymes act at key steps of glucose metabolism: transketolase in the pentose shunt, pyruvate dehydrogenase complex linking glycolysis and the tricarboxylic acid cycle, and the -ketoglutarate dehydrogenase complex in the TCA cycle. Glucose metabolism in the brain is unique in that it is much higher than in other tissues. The brain represents only 2% of body mass, but it uses 20% of the glucose. The high rate of metabolism may account for the brains sensitivity to thiamine deficiency. Another unique feature of brain glucose is that it also provides substrates for the synthesis of multiple neurotransmitters, including both glutamate and acetylcholine. The two major types of cognitive drugs approved for the treatment of AD interact with these two neurotransmitters, as epitomized by memantine and cholinesterase inhibitors . Current methods to assess brain metabolism are limited. For example, FDG PET only measures the first step of metabolism, and it is likely that other changes precede alterations measured by FDG PET.
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Thiamine Is Useful For Many Diseases
Since thiamine is used for the treatment of chronic diseases, it is acceptable to drink it in tablets, capsules or dragees. If a rapid action of a substance is required, it is advisable to administer the drug intravenously. It can help to fight against Anorexia, diarrhea or atonic constipation, Nervousness or apathy, Low reflex neuropathy, Muscle weakness, Hoarseness, Symptom dangling head, Heart failure, Megaloblastic anemia, Coronary heart disease, Atherosclerosis, Rheumatic heart disease, Neuritis and polyneuritis, Viral hepatitis, Neuralgia, Radiculitis, Thyrotoxicosis, Pyoderma, Psoriasis, eczema, Versicolor and Lactation.
What Does Vitamin B
Thiamine: A vitamin workhorse
Thiamine is an essential nutrient that all tissues of the body need to function properly. Thiamine was the first B vitamin that scientists discovered. This is why its name carries the number 1. Like the other B vitamins, thiamine is water-soluble and helps the body turn food into energy. You can find it in:
- individual supplements
The body needs thiamine to make adenosine triphosphate . This is a molecule that transports energy within cells.
A thiamine deficiency can impact many different functions of your body, including those of the:
Thankfully, thiamine deficiency is uncommon in the developed world. Thiamine deficiency is rare in healthy adults. Its more common in people with specific medical conditions. Conditions that can impair thiamine levels include:
People who are undergoing dialysis for their kidneys or taking loop diuretics are also at risk for thiamine deficiency. Loop diuretics are prescribed for people with congestive heart failure. They can flush thiamine out of the body, possibly canceling out any health benefits. The heart relies on thiamine to function properly. People who take digoxin and phenytoin should also be careful.
Either disease can be treated with thiamine injections or supplements. This may help with vision and muscular difficulties. However, thiamine cant mend the permanent memory damage caused by Korsakoff syndrome.
Scientists have looked at thiamine as a possible treatment for:
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Vitamin B1 Recommended Dosage
The recommended dosage of Vitamin B1 according to the American FDA is 1.2 mg per day. Pregnant and breastfeeding women is a whopping 1.4 mg per day.
Many neurohackers would laugh at these recommendations. Mild thiamine deficiency affects a significant segment of the population in any country.
Most clinical studies use thiamine doses from 300 up to 1800 mg per day.
The bottom-line is thiamine dosing is completely up to you. No side effects are reported even at higher doses.
The Mayo Clinic recommends:
- Menstrual cramps 100 mg per day
- Epilepsy 50 mg per day
- Alcoholic liver disease and withdrawal 100 mg injections of thiamine hydrochloride
- Coma or hypothermia 100 mg injections
- Thiamine deficiency due to nutrition 100 mg injections
- Wernicke-Korsakoff Syndrome 5 200 mg injections
Some natural health clinics offer thiamine therapy intravenously and doses are usually 25 50 mg per session.
